Description

4-(Azetidin-3-Ylmethoxy)-Benzonitrile is a high-purity, advanced pharmaceutical intermediate featuring a unique molecular scaffold. This compound is of significant value for medicinal chemistry research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers focused on developing new therapeutic agents, especially within central nervous system (CNS) and oncology drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates in preclinical and clinical development.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its azetidine and benzonitrile motifs.
• Protease Inhibitor Development: Serves as a core scaffold in the research of inhibitors targeting various enzymes.
• Kinase Inhibitor Synthesis: Employed in the construction of potential kinase inhibitors for oncology and inflammatory disease applications.
• Chemical Biology Probes: Utilized to create tool compounds for studying biological pathways and target validation.
• Custom Synthesis: A starting material for contract manufacturing organizations (CMOs) producing bespoke compounds for client research.

Basic Information

Product Name	4-(Azetidin-3-Ylmethoxy)-Benzonitrile
CAS No.	954224-39-6
Molecular Formula	C11H12N2O
Molecular Weight	188.23 g/mol
Synonyms	4-[(Azetidin-3-yl)methoxy]benzonitrile; 4-(Azetidin-3-ylmethoxy)benzonitrile; Benzonitrile, 4-[(3-azetidinyl)methoxy]-; 4-(Azetidine-3-ylmethoxy)benzonitrile; 954224-39-6; 4-(3-Azetidinylmethoxy)benzonitrile; AZD1283 Intermediate; Potential EGFR Inhibitor Intermediate
EINECS	Contact for details

Quality Control

Our 4-(Azetidin-3-Ylmethoxy)-Benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring the material is suitable for advanced research and development purposes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, containers should be kept tightly sealed and under an inert atmosphere for long-term storage to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.