Description

tert-Butyl n-[(1,2,3,4-Tetrahydroquinolin-2-Yl)Methyl]Carbamate is a high-purity, advanced pharmaceutical intermediate used in the synthesis of complex active pharmaceutical ingredients (APIs). This compound is critical for research and development in medicinal chemistry, offering a protected amine functionality essential for constructing sophisticated nitrogen-containing heterocycles. It is primarily utilized by pharmaceutical manufacturers and contract research organizations (CROs) focused on developing novel therapeutic agents, particularly in the areas of central nervous system (CNS) and cardiovascular drug discovery.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of novel drug candidates, especially those containing tetrahydroquinoline scaffolds.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic molecules.
• API Synthesis: Serves as a critical precursor in the commercial-scale production of active pharmaceutical ingredients for clinical trials and market supply.
• Chemical Biology Probes: Employed in the development of specialized probes and tools for studying biological pathways and target validation.
• Custom Synthesis: A starting material for contract manufacturing organizations (CMOs) offering bespoke chemical synthesis services.
• Academic Research: Utilized in university and institutional labs for fundamental research in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	tert-Butyl n-[(1,2,3,4-Tetrahydroquinolin-2-Yl)Methyl]Carbamate
CAS No.	953903-48-5
Molecular Formula	C16H24N2O2
Molecular Weight	276.38 g/mol
Synonyms	Boc-2-AMTMQ; tert-Butyl (2-aminomethyl-1,2,3,4-tetrahydroquinolin-2-yl)carbamate; N-Boc-2-(aminomethyl)-1,2,3,4-tetrahydroquinoline; 1,2,3,4-Tetrahydro-N-[(1,1-dimethylethoxy)carbonyl]-2-quinolinemethanamine; 2-((((tert-Butoxy)carbonyl)amino)methyl)-1,2,3,4-tetrahydroquinoline; (2-((tert-Butoxycarbonyl)amino)methyl)-1,2,3,4-tetrahydroquinoline; tert-Butyl N-[(1,2,3,4-tetrahydro-2-quinolinyl)methyl]carbamate
EINECS	Contact for details

Quality Control

Our tert-Butyl n-[(1,2,3,4-Tetrahydroquinolin-2-Yl)Methyl]Carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); containers must be kept tightly sealed to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.