Description

5-Fluoro-8-Methyl-1,2,3,4-Tetrahydroquinoline is a high-purity, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters because its unique fused-ring structure, incorporating both fluorine and a tetrahydroquinoline scaffold, provides a versatile platform for creating novel molecules with tailored properties. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and material science. The CAS number for this compound is 953714-92-6.

Application

This specialized chemical intermediate serves as a critical precursor in several high-value research and development areas:

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research, where the fluorine atom can enhance metabolic stability and bioavailability.
• Agrochemical Research: Used in developing new active ingredients for crop protection products, leveraging the structural motif for potential insecticidal or herbicidal activity.
• Ligand and Catalyst Development: The nitrogen-containing heterocycle can be functionalized to create novel ligands for asymmetric catalysis or metal-organic frameworks (MOFs).
• Material Science Precursor: Serves as a starting material for synthesizing advanced organic electronic materials or fluorescent dyes.
• Academic & Contract Research: Essential for fundamental organic chemistry research and for contract research organizations (CROs) working on custom synthesis projects.

Basic Information

Product Name	5-Fluoro-8-Methyl-1,2,3,4-Tetrahydroquinoline
CAS No.	953714-92-6
Molecular Formula	C10H12FN
Molecular Weight	165.21 g/mol
Synonyms	8-Methyl-5-fluoro-1,2,3,4-tetrahydroquinoline; 5-Fluoro-8-methyl-1,2,3,4-tetrahydroquinoline; 1,2,3,4-Tetrahydro-5-fluoro-8-methylquinoline; 953714-92-6; 5-Fluoro-8-methyl-THQ; 8-Methyl-5-fluoro-THQ
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure batch-to-batch consistency and compliance with research-grade standards. We employ advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry for precise characterization. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your critical R&D work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive (store away from light). Keep container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Research Grade)
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.