Description

8-Quinazolinol, 2-Chloro-5-(Trifluoromethyl)- is a high-purity, advanced pharmaceutical intermediate characterized by its halogenated quinazoline core structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of next-generation drugs, agrochemicals, and specialized organic materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, especially kinase inhibitors and other small molecule therapeutics.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and pesticides due to its bioactive quinazoline moiety.
• Chemical Synthesis: Serves as a versatile precursor in organic chemistry for constructing complex heterocyclic compounds.
• Material Science: Investigated for use in the development of organic electronic materials and advanced polymers.
• Biochemical Research: Employed as a standard or reagent in biochemical assays and proteomics research.

Basic Information

Product Name	8-Quinazolinol, 2-Chloro-5-(Trifluoromethyl)-
CAS No.	953040-23-8
Molecular Formula	C9H4ClF3N2O
Molecular Weight	248.59 g/mol
Synonyms	2-Chloro-5-(trifluoromethyl)quinazolin-8-ol; 2-Chloro-5-(trifluoromethyl)-8-hydroxyquinazoline; 8-Hydroxy-2-chloro-5-(trifluoromethyl)quinazoline; 953040-23-8; Quinazolin-8-ol, 2-chloro-5-(trifluoromethyl)-; 2-Chloro-5-trifluoromethyl-8-quinazolinol
EINECS	Contact for details

Quality Control

Our 8-Quinazolinol, 2-Chloro-5-(Trifluoromethyl)- is manufactured under a strict quality management system to ensure batch-to-batch consistency and high purity. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support cGMP compliance for pharmaceutical applications and can accommodate custom purity requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong acids, bases, and oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.