Description

2-tert-Butyl-6-Fluoro-5-Nitro-1H-Indole is a high-purity, multi-functional heterocyclic building block, identified by CAS NO 952664-72-1. This compound is valued for its unique molecular architecture, which combines a sterically hindered tert-butyl group with electron-withdrawing nitro and fluoro substituents on the indole scaffold, making it a critical intermediate in advanced synthetic chemistry. It is primarily sought after by research institutions and pharmaceutical development companies for the synthesis of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting neurological and oncological pathways.
• Agrochemical Research: Used in the development of new herbicides and fungicides, leveraging its fluorinated nitro-indole structure for bioactivity.
• Material Science: Serves as a building block for organic semiconductors, dyes, and photoactive polymers due to its electron-deficient aromatic system.
• Academic & R&D: Employed in medicinal chemistry programs for structure-activity relationship (SAR) studies and library synthesis.
• Chemical Synthesis: Acts as a versatile scaffold for further functionalization, including palladium-catalyzed cross-coupling reactions.

Basic Information

Item	Details
Product Name	2-tert-Butyl-6-Fluoro-5-Nitro-1H-Indole
CAS No.	952664-72-1
Molecular Formula	C₁₂H₁₃FN₂O₂
Molecular Weight	236.24 g/mol
Synonyms	2-(1,1-Dimethylethyl)-6-fluoro-5-nitro-1H-indole; 2-tert-Butyl-6-fluoro-5-nitroindole; 6-Fluoro-5-nitro-2-tert-butyl-1H-indole; 952664-72-1; 2-tert-Butyl-6-fluoro-5-nitroindole; 5-Nitro-6-fluoro-2-tert-butylindole; 2-(tert-Butyl)-6-fluoro-5-nitro-1H-indole
EINECS	Contact for details

Quality Control

Our 2-tert-Butyl-6-Fluoro-5-Nitro-1H-Indole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and industry best practices for research-grade chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is easily oxidized and should be handled under an inert atmosphere for long-term stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.