Description

4(1H)-Quinolinone, 2-Ethyl-2,3-dihydro-6-(trifluoromethyl)-, (2R)- is a high-purity, chiral dihydroquinolinone derivative of significant interest in advanced organic synthesis. Its core value lies in its unique molecular scaffold, which incorporates a stereogenic center and a trifluoromethyl group, making it a critical pharmaceutical intermediate for the development of novel active ingredients. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to build complex, fluorinated heterocyclic systems.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of potential drug candidates, particularly in central nervous system (CNS) and oncology research.
• Agrochemical Research: Used in the development of new herbicides and pesticides, where the trifluoromethyl group can enhance biological activity and metabolic stability.
• Ligand and Catalyst Development: Acts as a precursor for creating novel chiral ligands or organocatalysts used in asymmetric synthesis.
• Material Science Precursor: Explored for the synthesis of advanced organic materials, such as fluorinated liquid crystals or electronic materials.
• Chemical Biology Probe: Utilized in the design of molecular probes to study enzyme mechanisms or protein-ligand interactions.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial-scale production of complex molecules.

Basic Information

Item	Detail
Product Name	4(1H)-Quinolinone, 2-Ethyl-2,3-dihydro-6-(trifluoromethyl)-, (2R)-
CAS No.	952582-00-2
Molecular Formula	C₁₂H₁₂F₃NO
Molecular Weight	243.23 g/mol
Synonyms	(2R)-2-Ethyl-2,3-dihydro-6-(trifluoromethyl)-4(1H)-quinolinone; (R)-2-Ethyl-6-(trifluoromethyl)-1,2-dihydro-4-quinolone; (R)-2-Ethyl-6-(trifluoromethyl)-1,2-dihydroquinolin-4(3H)-one; (2R)-2-Ethyl-6-(trifluoromethyl)-1,2-dihydro-4-quinolone; 952582-00-2; (R)-enantiomer of 2-ethyl-6-(trifluoromethyl)-1,2-dihydroquinolin-4-one; Chiral Dihydroquinolinone Derivative
EINECS	Contact for details

Quality Control

Our 4(1H)-Quinolinone, 2-Ethyl-2,3-dihydro-6-(trifluoromethyl)-, (2R)- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and standard identification methods, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing purity, chiral excess, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). This compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.