Description

4-Methyl-6-(trifluoromethoxy)quinolin-2-ol is a high-purity, advanced pharmaceutical intermediate and organic building block. This compound is valued for its unique quinoline scaffold functionalized with a trifluoromethoxy group, which is critical for modulating the biological activity and physicochemical properties of target molecules. It is primarily required by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly in therapeutic areas targeting central nervous system (CNS) disorders, inflammation, and infectious diseases.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, where the trifluoromethoxy group can enhance metabolic stability and bioavailability.
• Material Science: Acts as a functional monomer or ligand in the creation of advanced organic electronic materials, such as OLEDs or conductive polymers.
• Chemical Synthesis: Employed as a versatile building block in organic chemistry for constructing complex heterocyclic compounds via cross-coupling and cyclization reactions.
• Biochemical Tool Compound: Utilized in life science research as a probe or inhibitor to study specific enzymatic pathways or biological mechanisms.

Basic Information

Product Name	4-Methyl-6-(trifluoromethoxy)quinolin-2-ol
CAS No.	952443-82-2
Molecular Formula	C₁₁H₈F₃NO₂
Molecular Weight	243.18 g/mol
Synonyms	2-Hydroxy-4-methyl-6-(trifluoromethoxy)quinoline; 6-(Trifluoromethoxy)-4-methylquinolin-2-ol; 4-Methyl-6-(trifluoromethoxy)-2-quinolinol; 4-Methyl-6-trifluoromethoxy-quinolin-2-ol; 952443-82-2; Quinolin-2-ol, 4-methyl-6-(trifluoromethoxy)-; 4-Methyl-6-(trifluoromethoxy)quinolin-2(1H)-one (tautomer)
EINECS	Contact for details

Quality Control

Our 4-Methyl-6-(trifluoromethoxy)quinolin-2-ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.