Description

1-[3-(Trifluoromethyl)Benzyl]-1H-1,2,3-Triazole-4-Carbaldehyde is a specialized heterocyclic building block featuring a benzyl-triazole core functionalized with a reactive aldehyde group and a trifluoromethyl substituent. This compound is valued for its role as a versatile intermediate in the synthesis of complex molecules, particularly in pharmaceutical and agrochemical research where the introduction of fluorine atoms and click chemistry handles is critical. It is primarily sought by R&D chemists and process development scientists in the life sciences sector for constructing novel active ingredients, chemical probes, and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, especially in medicinal chemistry programs targeting kinase inhibitors, antiviral agents, and anti-inflammatory compounds.
• Agrochemical Research: Used in the synthesis of novel pesticides and herbicides, where the trifluoromethyl group can enhance biological activity and metabolic stability.
• Click Chemistry: Serves as a functionalized precursor in Huisgen 1,3-dipolar cycloaddition reactions for bioconjugation, polymer modification, and material science applications.
• Ligand and Catalyst Development: Employed in the creation of novel chelating ligands and organocatalysts for asymmetric synthesis.
• Chemical Biology Probe Synthesis: Utilized to build activity-based probes and fluorescent tags for studying biological pathways and protein functions.
• Advanced Material Precursor: Acts as a monomer or cross-linker in the development of specialty polymers and functional coatings.

Basic Information

Product Name	1-[3-(Trifluoromethyl)Benzyl]-1H-1,2,3-Triazole-4-Carbaldehyde
CAS No.	952183-29-8
Molecular Formula	C11H8F3N3O
Molecular Weight	255.20 g/mol
Synonyms	1-[(3-Trifluoromethyl)benzyl]-1H-1,2,3-triazole-4-carboxaldehyde; 1-(3-Trifluoromethylbenzyl)-1H-1,2,3-triazole-4-carbaldehyde; 4-Formyl-1-[(3-trifluoromethyl)benzyl]-1,2,3-triazole; 1-(3-(Trifluoromethyl)benzyl)-1H-1,2,3-triazole-4-carbaldehyde; 1H-1,2,3-Triazole-4-carboxaldehyde, 1-[[3-(trifluoromethyl)phenyl]methyl]-; 1-(α,α,α-Trifluoro-m-tolyl)methyl-1H-1,2,3-triazole-4-carboxaldehyde
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is characterized and controlled using advanced analytical techniques to guarantee identity, purity, and consistency. Certificates of Analysis (COA) detailing specific results for purity, impurities, and other critical parameters are available upon request. We support development and commercial projects with material suitable for research and non-GMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is easily oxidized and should be handled under an inert atmosphere when appropriate for prolonged use. Keep away from incompatible materials such as strong reducing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.