Description

4-Chloro-7-Methoxy-2-Trifluoromethyl-Quinazoline is a high-value, multi-functional heterocyclic building block designed for advanced chemical synthesis. Its core value lies in its unique trifluoromethyl and chloro substituents, which are critical for modulating the physicochemical and biological properties of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors, anticancer agents, and other biologically active quinazoline derivatives.
• Agrochemical Development: Used in the research and production of advanced herbicides and fungicides, where the trifluoromethyl group enhances activity and environmental stability.
• Material Science Research: Serves as a building block for creating novel organic electronic materials, such as OLEDs and semiconductors.
• Chemical Synthesis: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to introduce complex quinazoline scaffolds.
• Fluorine Chemistry: A valuable source of a trifluoromethylated heterocycle for studying structure-activity relationships (SAR) in drug discovery.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for proprietary synthesis projects requiring high-purity, specialized intermediates.

Basic Information

Product Name	4-Chloro-7-Methoxy-2-Trifluoromethyl-Quinazoline
CAS No.	951904-99-7
Molecular Formula	C10H6ClF3N2O
Molecular Weight	262.61 g/mol
Synonyms	2-Trifluoromethyl-4-chloro-7-methoxyquinazoline; 4-Chloro-7-methoxy-2-(trifluoromethyl)quinazoline; 7-Methoxy-4-chloro-2-trifluoromethylquinazoline; Quinazoline, 4-chloro-7-methoxy-2-(trifluoromethyl)-; 951904-99-7; 4-Chloro-7-methoxy-2-trifluoromethyl-quinazoline
EINECS	Contact for details

Quality Control

Every batch of 4-Chloro-7-Methoxy-2-Trifluoromethyl-Quinazoline is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with each shipment to guarantee it meets your specific R&D or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area%)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.