Description

1-Fmoc-3-Amino-3-(Hydroxymethyl)Pyrrolidine is a high-purity, multifunctional building block designed for advanced organic synthesis and pharmaceutical research. This compound is critical for the efficient construction of complex molecular architectures, particularly in peptide and peptidomimetic chemistry. It is an essential reagent for medicinal chemists and process development scientists working in drug discovery, agrochemical research, and the development of novel bioactive compounds.

Application

• Peptide Synthesis: Serves as a key Fmoc-protected amino acid derivative for solid-phase peptide synthesis (SPPS), enabling the incorporation of constrained pyrrolidine scaffolds.
• Pharmaceutical Intermediates: Used in the research and development of active pharmaceutical ingredients (APIs), particularly for protease inhibitors and other therapeutic agents.
• Peptidomimetic Design: A crucial building block for creating peptidomimetics, which are molecules that mimic peptides but with enhanced metabolic stability and bioavailability.
• Chemical Biology Probes: Employed in the synthesis of labeled compounds and molecular probes for studying biological pathways and target engagement.
• Agrochemical Research: Utilized as an intermediate in the development of novel pesticides and herbicides with specific biological activity.
• Material Science: Potential use in the synthesis of specialized polymers and dendrimers with unique structural properties.

Basic Information

Product Name	1-Fmoc-3-Amino-3-(Hydroxymethyl)Pyrrolidine
CAS No.	951625-98-2
Molecular Formula	C₂₁H₂₄N₂O₃
Molecular Weight	352.43 g/mol
Synonyms	Fmoc-3-Amino-3-(hydroxymethyl)pyrrolidine; 3-(Hydroxymethyl)-3-(9H-fluoren-9-ylmethoxycarbonylamino)pyrrolidine; 1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-amino-3-(hydroxymethyl)pyrrolidine; N-α-Fmoc-3-amino-3-(hydroxymethyl)pyrrolidine; Fmoc-Amp(3-OH)-OH; (3R/S)-3-(Fmoc-amino)-3-(hydroxymethyl)pyrrolidine; Fmoc-3-Amp(3-OH)
EINECS	Contact for details

Quality Control

Our 1-Fmoc-3-Amino-3-(Hydroxymethyl)Pyrrolidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide Certificates of Analysis (COA) with each shipment, detailing all specification results to ensure traceability and compliance with your research or cGMP guidelines for early-phase development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.