Description

L-(-)-Histidinol Dihydrochloride is a high-purity, chiral amino alcohol derivative essential for advanced biochemical research and synthesis. This compound serves as a critical intermediate and building block in the development of pharmaceuticals and fine chemicals. It is particularly valuable for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors requiring precise stereochemical control.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of histidine analogs, enzyme inhibitors, and other active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a precursor in metabolic pathway studies, enzyme-substrate interaction research, and as a tool compound in microbiology.
• Peptide Synthesis: Serves as a protected form of L-histidinol for use in solid-phase and solution-phase peptide synthesis.
• Cell Culture & Media Supplement: Employed in specialized microbiological media and cell culture applications as a nutrient or selective agent.
• Reference Standard: Utilized as an analytical standard in quality control laboratories for HPLC, LC-MS, and other chromatographic methods.
• Asymmetric Synthesis Catalyst: Acts as a ligand or chiral auxiliary in metal-catalyzed asymmetric transformations.

Basic Information

Product Name	L-(-)-Histidinol Dihydrochloride
CAS No.	1596-64-1
Molecular Formula	C6H11N3O · 2HCl
Molecular Weight	230.10 g/mol
Synonyms	L-Histidinol dihydrochloride; (S)-(-)-2-Amino-3-(1H-imidazol-4-yl)-1-propanol dihydrochloride; Histidinol hydrochloride; L-Histidinol HCl; (S)-Histidinol dihydrochloride; 4-(2-Amino-3-hydroxypropyl)imidazole dihydrochloride; L-2-Amino-3-(4-imidazolyl)-1-propanol dihydrochloride
EINECS	216-476-4

Quality Control

Our L-(-)-Histidinol Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]20/D	-10.0° to -12.0° (c=1 in H2O)
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.