Description

6-Bromo-4-Chloro-7-Fluoroquinazoline is a high-purity, multi-halogenated quinazoline derivative serving as a critical building block in advanced organic synthesis. Its unique halogen substitution pattern makes it an indispensable intermediate for the development of targeted small-molecule pharmaceuticals, particularly kinase inhibitors. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and process development of novel anticancer and anti-inflammatory agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of tyrosine kinase inhibitors (TKIs) and other targeted therapeutic agents.
• Medicinal Chemistry Research: Used extensively in structure-activity relationship (SAR) studies and lead optimization campaigns for drug discovery.
• Process Chemistry: Serves as a versatile scaffold for scale-up and manufacturing route development of active pharmaceutical ingredients (APIs).
• Biochemical Tool Compound: Employed in the development of chemical probes for studying kinase signaling pathways and cellular mechanisms.
• Agrochemical Research: Investigated as an intermediate for novel crop protection agents and herbicides.

Basic Information

Product Name	6-Bromo-4-Chloro-7-Fluoroquinazoline
CAS No.	950577-03-4
Molecular Formula	C8H3BrClFN2
Molecular Weight	261.48 g/mol
Synonyms	6-Bromo-4-chloro-7-fluoroquinazoline; 4-Chloro-6-bromo-7-fluoroquinazoline; 7-Fluoro-6-bromo-4-chloroquinazoline; Quinazoline, 6-bromo-4-chloro-7-fluoro-; 950577-03-4; BCFQ
EINECS	Contact for details

Quality Control

Every batch of 6-Bromo-4-Chloro-7-Fluoroquinazoline is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure compliance with stringent internal specifications suitable for research and pharmaceutical development. A detailed Certificate of Analysis (COA) providing purity, identity, and impurity profiles is supplied with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.