Description

2,8-Bis(Trifluoromethyl)-4-Hydroxyquinoline is a high-value, fluorinated quinoline derivative characterized by its unique trifluoromethyl substituents. This compound serves as a critical advanced pharmaceutical intermediate (API) and a versatile building block in organic synthesis, enabling the introduction of fluorine atoms to enhance the metabolic stability and bioavailability of target molecules. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and material science sectors for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used as a building block for developing advanced pesticides and herbicides, where the fluorine atoms improve lipophilicity and environmental stability.
• Material Science: Serves as a monomer or additive in the creation of specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing properties.
• Organic Synthesis & Catalysis: Acts as a ligand or a complex scaffold in catalytic systems and in the preparation of more complex fluorinated heterocyclic compounds.
• Research & Development: Essential for medicinal chemistry programs in academic and industrial R&D labs for structure-activity relationship (SAR) studies.
• Fluorine Chemistry: A valuable reagent for introducing trifluoromethyl groups into molecular architectures, a common strategy in modern drug design.

Basic Information

Product Name	2,8-Bis(Trifluoromethyl)-4-Hydroxyquinoline
CAS No.	949507-83-9
Molecular Formula	C11H5F6NO
Molecular Weight	281.16 g/mol
Synonyms	4-Hydroxy-2,8-bis(trifluoromethyl)quinoline; 2,8-Bis(trifluoromethyl)quinolin-4-ol; 4-Quinolinol, 2,8-bis(trifluoromethyl)-; 949507-83-9; 2,8-Bis(trifluoromethyl)-4-quinolinol; 2,8-Bis(trifluoromethyl)-4-hydroxyquinoline; 4-Hydroxy-2,8-di(trifluoromethyl)quinoline
EINECS	Contact for details

Quality Control

Our 2,8-Bis(Trifluoromethyl)-4-Hydroxyquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and reliability for critical R&D and production applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive). Keep away from strong acids/bases and oxidizing agents. For long-term storage, consider using an inert atmosphere to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.