Description

(R)-5-(2-Azido-1-((tert-Butyldimethylsilyl)Oxy)Ethyl)-8-(Benzyloxy)Quinolin-2(1H)-One is a sophisticated chiral synthetic intermediate of significant interest in advanced pharmaceutical research and development. This compound is valued for its unique molecular architecture, which incorporates a protected hydroxyl group, an azide functionality, and a quinolinone core, making it a versatile building block for complex molecule synthesis. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and biotechnology sectors for constructing novel active pharmaceutical ingredients (APIs) and exploring new chemical entities.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of complex drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns to develop new pharmacophores.
• Process Chemistry Development: Employed in scaling up synthetic routes for potential Active Pharmaceutical Ingredients (APIs) under Good Manufacturing Practice (GMP) conditions.
• Click Chemistry Applications: The azide group enables participation in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions for bioconjugation and polymer chemistry.
• Asymmetric Synthesis: Utilized as a chiral template or reagent in the development of enantioselective synthetic methodologies.
• Academic & Institutional Research: A valuable compound for universities and research institutes exploring novel heterocyclic chemistry and synthetic pathways.

Basic Information

Product Name	(R)-5-(2-Azido-1-((tert-Butyldimethylsilyl)Oxy)Ethyl)-8-(Benzyloxy)Quinolin-2(1H)-One
CAS No.	948893-91-2
Molecular Formula	C24H30N4O3Si
Molecular Weight	450.61 g/mol
Synonyms	(R)-5-(2-Azido-1-((tert-Butyldimethylsilyl)oxy)ethyl)-8-(benzyloxy)-1,2-dihydroquinolin-2-one; (R)-8-(Benzyloxy)-5-[2-azido-1-[(tert-butyldimethylsilyl)oxy]ethyl]quinolin-2(1H)-one; 2(1H)-Quinolinone, 5-[2-azido-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-8-(phenylmethoxy)-, (R)-; TBS-protected azidoethyl quinolinone intermediate; (R)-enantiomer of CAS 948893-91-2
EINECS	Contact for details

Quality Control

Our production of (R)-5-(2-Azido-1-((tert-Butyldimethylsilyl)Oxy)Ethyl)-8-(Benzyloxy)Quinolin-2(1H)-One adheres to stringent internal quality standards designed for research and development use. Each batch is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, high chemical purity, and chiral integrity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profile is provided with every shipment to ensure traceability and support your regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive and should be handled under appropriate conditions to prevent degradation. Keep away from strong oxidizers. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.