Description

(R)-2-[Bis(3,5-Dimethylphenyl)Methoxymethyl)Pyrrolidine Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant commercial interest. Its value lies in its role as a key precursor in the synthesis of complex molecules, particularly for active pharmaceutical ingredients (APIs) requiring specific stereochemistry. This compound is essential for research and development chemists and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality intermediates for asymmetric synthesis and process development.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the research and production of novel therapeutic agents, particularly in central nervous system (CNS) and cardiovascular drug candidates.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for the synthesis of sophisticated chiral ligands used in enantioselective catalytic reactions.
• Agrochemical Synthesis: Used in the development of advanced, stereochemically pure pesticides and herbicides.
• Academic & Industrial R&D: A valuable tool for method development in organic synthesis and for studying structure-activity relationships (SAR) in medicinal chemistry.
• Fine Chemical Production: Employed in the multi-step synthesis of complex, high-value specialty chemicals where optical purity is paramount.

Basic Information

Product Name	(R)-2-[Bis(3,5-Dimethylphenyl)Methoxymethyl)Pyrrolidine Hydrochloride
CAS No.	948595-02-6
Molecular Formula	C25H34ClNO
Molecular Weight	400.00 g/mol (approx.)
Synonyms	(R)-2-((Bis(3,5-dimethylphenyl)methoxy)methyl)pyrrolidine hydrochloride; (R)-2-[Bis(3,5-dimethylphenyl)methoxymethyl]pyrrolidine HCl; (R)-2-((Di(3,5-xylyl)methoxy)methyl)pyrrolidine hydrochloride; (R)-Di(3,5-xylyl)methoxymethylpyrrolidine HCl; (R)-XYLOPHOS precursor; Chiral pyrrolidine derivative hydrochloride; (R)-Bis(3,5-dimethylphenyl)(pyrrolidin-2-ylmethoxy)methane hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-2-[Bis(3,5-Dimethylphenyl)Methoxymethyl)Pyrrolidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity (enantiomeric excess) and chemical purity determination by HPLC, to ensure it meets the stringent requirements for advanced synthetic applications. A Certificate of Analysis (COA) detailing identity, purity, and specific test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (ee)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.