Description

Tetrabutylammonium Fluoride is a highly versatile and powerful phase-transfer catalyst and fluorinating agent. Its primary value lies in its ability to facilitate reactions between reagents in immiscible phases, significantly enhancing reaction rates and yields in organic synthesis. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, where it is used to introduce fluorine atoms or to drive challenging synthetic transformations.

Application

• Phase-Transfer Catalyst (PTC): Widely employed to accelerate reactions between ionic reagents in aqueous phases and organic substrates in non-polar solvents.
• Fluorination Reactions: A key reagent for nucleophilic fluorination, including the conversion of alkyl halides, tosylates, and mesylates to the corresponding alkyl fluorides.
• Desilylation Agent: Effectively removes silyl protecting groups (e.g., TMS, TBDMS, TIPS) in synthetic organic chemistry, particularly for deprotecting silyl ethers.
• Pharmaceutical Intermediate Synthesis: Critical in the preparation of fluorinated drug candidates and active pharmaceutical ingredients (APIs) where fluorine incorporation is desired for metabolic stability or bioavailability.
• Polymer and Materials Science: Used in the synthesis and modification of specialty polymers and advanced materials, including liquid crystals and electronic chemicals.
• Agrochemical Manufacturing: Facilitates the synthesis of fluorinated pesticides and herbicides, enhancing their efficacy and environmental profile.

Basic Information

Product Name	Tetrabutylammonium Fluoride
CAS No.	22206-57-1
Molecular Formula	C16H36FN
Molecular Weight	261.46 g/mol
Synonyms	TBAF; Tetra-n-butylammonium Fluoride; N,N,N-Tributyl-1-butanaminium Fluoride; 1-Butanaminium, N,N,N-tributyl-, fluoride (1:1); Fluorotributylhexadecylammonium; Tetrabutylammonium fluoride solution; TBAF trihydrate
EINECS	244-826-1

Quality Control

Our Tetrabutylammonium Fluoride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets precise specifications for purity, identity, and performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, water content, and impurity profiles. Our quality commitment supports applications requiring high consistency and reliability, from research and development to commercial-scale production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions to prevent decomposition. Keep the container tightly sealed when not in use and consider storage under an inert atmosphere for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or solution
Identification (IR)	Conforms to structure
Assay (Titration)	≥ 97.0% (anhydrous basis)
Water Content (KF)	≤ 3.0%
Heavy Metals (as Pb)	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.