Description

3-Chloromethyl-2,5-Dichloro-8-Methylquinoline is a versatile halogenated quinoline derivative that serves as a critical synthetic intermediate in advanced organic chemistry. Its multi-functional structure, featuring reactive chloromethyl and chloro substituents, makes it a valuable building block for constructing complex molecular architectures. This compound is primarily utilized by research institutions and industrial R&D departments in the pharmaceutical and agrochemical sectors for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel quinoline-based drug candidates, including potential antimicrobials, anticancer agents, and kinase inhibitors.
• Agrochemical Synthesis: Building block for developing new-generation pesticides, herbicides, and fungicides with enhanced efficacy and selectivity.
• Material Science Research: Used in the creation of functional organic materials, such as ligands for metal-organic frameworks (MOFs) or components for organic electronics.
• Chemical Biology Probes: Serves as a scaffold for developing fluorescent probes or affinity tags to study biological processes.
• Cross-Coupling Reactions: The chloro substituents make it a suitable substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to create diverse compound libraries.
• Academic & Contract Research: Essential reagent for methodological development and exploratory synthesis in university and CRO laboratories.

Basic Information

Product Name	3-Chloromethyl-2,5-Dichloro-8-Methylquinoline
CAS No.	948292-13-5
Molecular Formula	C12H8Cl3N
Molecular Weight	264.56 g/mol
Synonyms	2,5-Dichloro-8-methyl-3-(chloromethyl)quinoline; 3-(Chloromethyl)-2,5-dichloro-8-methylquinoline; Quinoline, 3-(chloromethyl)-2,5-dichloro-8-methyl-; 8-Methyl-2,5-dichloro-3-chloromethylquinoline
EINECS	Contact for details

Quality Control

Our 3-Chloromethyl-2,5-Dichloro-8-Methylquinoline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment and NMR for structural confirmation. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment. We support custom synthesis and can tailor purity grades to meet specific research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.