Description

2-Chloro-6-Fluoroquinoline-3-Carbonitrile is a high-purity, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. This compound matters as a versatile and critical intermediate for constructing complex molecular architectures, particularly in the development of novel active pharmaceutical ingredients (APIs). It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and material science industries for creating new compounds with targeted biological or physical properties.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in kinase inhibitor and antimicrobial agent discovery.
• Agrochemical Synthesis: Used in the preparation of advanced fungicides, herbicides, and pesticides due to the bioactive quinoline core.
• Material Science Research: Serves as a precursor for the synthesis of organic semiconductors, liquid crystals, and fluorescent dyes.
• Chemical Biology: Employed as a molecular probe or scaffold in medicinal chemistry for structure-activity relationship (SAR) studies.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs performing bespoke chemical synthesis for clients.

Basic Information

Product Name	2-Chloro-6-Fluoroquinoline-3-Carbonitrile
CAS No.	948291-71-2
Molecular Formula	C10H4ClFN2
Molecular Weight	206.61 g/mol
Synonyms	2-Chloro-6-fluoro-3-cyanoquinoline; 2-Chloro-6-fluoroquinoline-3-carbonitrile; 3-Cyano-2-chloro-6-fluoroquinoline; Quinoline-3-carbonitrile, 2-chloro-6-fluoro-; 948291-71-2; 2-Chloro-6-fluoro-3-quinolinecarbonitrile
EINECS	Contact for details

Quality Control

Our 2-Chloro-6-Fluoroquinoline-3-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.