Description

tert-Butyl 4-Oxo-3,4-Dihydro-2H-Spiro[Naphthalene-1,4'-Piperidine]-1'-Carboxylate is a high-value, advanced pharmaceutical intermediate featuring a complex spirocyclic and fused ring structure. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel drug candidates with potential therapeutic applications. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of central nervous system (CNS) agents, kinase inhibitors, and other bioactive molecules targeting complex disease pathways.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new chemical entities (NCEs) and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing complex molecular architectures in drug discovery programs, particularly for CNS targets.
• Kinase Inhibitor Synthesis: Used in the preparation of potential kinase inhibitor candidates due to its spirocyclic piperidine moiety.
• Chemical Biology Probes: Employed in the development of tool compounds and probes for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, complex intermediates.

Basic Information

Product Name	tert-Butyl 4-Oxo-3,4-Dihydro-2H-Spiro[Naphthalene-1,4'-Piperidine]-1'-Carboxylate
CAS No.	948034-21-7
Molecular Formula	C19H23NO3
Molecular Weight	313.39 g/mol
Synonyms	1'-Boc-1,2,3,4-tetrahydrospiro[naphthalene-1,4'-piperidin]-4-one; tert-Butyl 4-oxo-1,2,3,4-tetrahydrospiro[naphthalene-1,4'-piperidine]-1'-carboxylate; 1,2,3,4-Tetrahydrospiro[naphthalene-1,4'-piperidin]-4-one, 1'-(1,1-dimethylethyl) ester; 1'-tert-Butoxycarbonyl-1,2,3,4-tetrahydrospiro[naphthalene-1,4'-piperidin]-4-one; 1'-Boc-1,2,3,4-tetrahydrospiro[naphthalene-1,4'-piperidin]-4-one; Spiro[naphthalene-1,4'-piperidine]-1'-carboxylic acid, 4-oxo-3,4-dihydro-2H-, 1,1-dimethylethyl ester; 948034-21-7
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-Oxo-3,4-Dihydro-2H-Spiro[Naphthalene-1,4'-Piperidine]-1'-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect from moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Single Unknown Impurity	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.