Description

tert-Butyl 5-Methyl-3-Oxo-2,3-Dihydrospiro[Indene-1,4'-Piperidine]-1'-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and piperidine scaffold. This compound is of significant value for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and metabolic disorder research. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in process development and scale-up for new drug candidates.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of novel drug candidates, especially those targeting neurological pathways.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry & Scale-Up: Used in the development and optimization of synthetic routes for the commercial production of complex target molecules.
• Reference Standard: Employed as an analytical standard for quality control and method validation in API manufacturing.
• Custom Synthesis: A starting material for the contract synthesis of specialized compounds for preclinical and clinical trials.

Basic Information

Product Name	tert-Butyl 5-Methyl-3-Oxo-2,3-Dihydrospiro[Indene-1,4'-Piperidine]-1'-Carboxylate
CAS No.	948033-85-0
Molecular Formula	C19H25NO3
Molecular Weight	315.41 g/mol
Synonyms	1'-Boc-5-methyl-3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]; tert-Butyl 5-methyl-3-oxospiro[indene-1,4'-piperidine]-1'-carboxylate; 5-Methyl-3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylic acid tert-butyl ester; 1,1-Dimethylethyl 5-methyl-3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate; Spiro[indene-1,4'-piperidine]-1'-carboxylic acid, 2,3-dihydro-5-methyl-3-oxo-, 1,1-dimethylethyl ester; 948033-85-0; Boc-5-methyl-3-oxo-spiro[indane-1,4'-piperidine]
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-Methyl-3-Oxo-2,3-Dihydrospiro[Indene-1,4'-Piperidine]-1'-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.