Description

tert-Butyl 5,6-Dimethoxy-3-Oxo-2,3-Dihydrospiro[Indene-1,4'-Piperidine]-1'-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its complex spirocyclic indene-piperidine structure. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of central nervous system (CNS) and other therapeutic agents, where its specific stereochemistry and functional groups are critical for biological activity.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug candidates, particularly those targeting neurological pathways.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new molecules with improved efficacy and safety profiles.
• API Development: Serves as a core scaffold for the production of Active Pharmaceutical Ingredients (APIs) under Good Manufacturing Practice (GMP) conditions.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up of novel chemical entities for clinical trials.
• Academic Research: Utilized in university and institutional labs for studying synthetic methodologies and exploring new chemical spaces in organic chemistry.

Basic Information

Product Name	tert-Butyl 5,6-Dimethoxy-3-Oxo-2,3-Dihydrospiro[Indene-1,4'-Piperidine]-1'-Carboxylate
CAS No.	948033-75-8
Molecular Formula	C20H27NO5
Molecular Weight	361.43 g/mol
Synonyms	1'-Boc-5,6-dimethoxy-3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]; 1'-tert-Butoxycarbonyl-5,6-dimethoxy-3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]; 5,6-Dimethoxy-3-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylic acid tert-butyl ester; tert-Butyl 5,6-dimethoxy-3-oxospiro[indene-1,4'-piperidine]-1'(2'H)-carboxylate; Spiro[indene-1,4'-piperidine]-1'-carboxylic acid, 5,6-dimethoxy-2,3-dihydro-3-oxo-, 1,1-dimethylethyl ester; 948033-75-8
EINECS	Contact for details

Quality Control

Our tert-Butyl 5,6-Dimethoxy-3-Oxo-2,3-Dihydrospiro[Indene-1,4'-Piperidine]-1'-Carboxylate is manufactured under strict quality systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and pre-clinical development. Certificates of Analysis (COA) detailing purity, impurities, and other critical parameters are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.