Description

2-(Chloromethyl)-8-Fluoro-4(1H)-Quinolinone (Saltdata: Free) is a high-purity, advanced pharmaceutical intermediate characterized by its quinolinone core functionalized with chloromethyl and fluoro substituents. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular modification. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new chemical entities, especially for anti-infective and targeted oncology applications.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug molecules, particularly fluoroquinolone analogs and other nitrogen-containing heterocycles.
• API Development: Used in research and development for creating new Active Pharmaceutical Ingredients (APIs) with potential antibacterial or anticancer activity.
• Chemical Synthesis: Serves as a versatile precursor for further functionalization via the reactive chloromethyl group in medicinal chemistry.
• Life Science Research: Employed in academic and industrial laboratories for biochemical studies and structure-activity relationship (SAR) investigations.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs offering bespoke chemical synthesis services.

Basic Information

Product Name	2-(Chloromethyl)-8-Fluoro-4(1H)-Quinolinone (Saltdata: Free)
CAS No.	946755-53-9
Molecular Formula	C10H7ClFNO
Molecular Weight	211.62 g/mol
Synonyms	8-Fluoro-2-(chloromethyl)-4(1H)-quinolinone; 2-(Chloromethyl)-8-fluoro-1H-quinolin-4-one; 8-Fluoro-2-(chloromethyl)-1H-quinolin-4-one; 4(1H)-Quinolinone, 2-(chloromethyl)-8-fluoro-; 946755-53-9; 2-Chloromethyl-8-fluoro-4-hydroxyquinoline
EINECS	Contact for details

Quality Control

Our production of 2-(Chloromethyl)-8-Fluoro-4(1H)-Quinolinone adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with customer specifications and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and reducing agents. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.