Description

2-(Chloromethyl)-6-Fluoro-4(1H)-Quinolinone (Saltdata: Free) is a high-purity, functionalized quinolinone derivative that serves as a critical building block in advanced organic synthesis. This compound matters because its unique molecular structure, featuring both chloromethyl and fluoro substituents, enables precise chemical modifications essential for developing novel active pharmaceutical ingredients (APIs) and specialty agrochemicals. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material sectors seeking to create new molecules with targeted biological or physical properties.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel quinoline-based drug candidates, particularly in oncology and anti-infective research.
• Agrochemical Development: Used in constructing advanced fungicides and herbicides where the fluorinated quinolinone core enhances bioactivity and environmental stability.
• Chemical Research: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Material Science Precursor: Potential intermediate for creating functionalized organic ligands used in catalysis or advanced polymeric materials.

Basic Information

Product Name	2-(Chloromethyl)-6-Fluoro-4(1H)-Quinolinone (Saltdata: Free)
CAS No.	946712-15-8
Molecular Formula	C10H7ClFNO
Molecular Weight	211.62 g/mol
Synonyms	6-Fluoro-2-(chloromethyl)-4(1H)-quinolinone; 2-(Chloromethyl)-6-fluoro-1H-quinolin-4-one; 6-Fluoro-2-(chloromethyl)-1H-quinolin-4-one; 4(1H)-Quinolinone, 2-(chloromethyl)-6-fluoro-; 946712-15-8; 2-Chloromethyl-6-fluoro-4-hydroxyquinoline; 6-Fluoro-2-chloromethyl-4-quinolone
EINECS	Contact for details

Quality Control

Our production of 2-(Chloromethyl)-6-Fluoro-4(1H)-Quinolinone adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content. Certificates of Analysis (COA) detailing all specifications are provided with every shipment, and we support custom purity requirements for research and cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.