Description

trans-n-Boc-1,4-Cyclohexanediamine-Hcl is a high-purity, protected diamine building block used extensively in advanced organic synthesis. This compound is critical for the controlled introduction of the 1,4-cyclohexanediamine moiety into complex molecular architectures, particularly in pharmaceutical research. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in oncology and antiviral research.
• Peptidomimetic Synthesis: Used to create conformationally constrained peptide analogs and protease inhibitors.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts in asymmetric synthesis.
• Polymer Chemistry: Monomer for the production of specialty polyamides and polyurethanes with unique thermal and mechanical properties.
• Agrochemical Synthesis: Intermediate in the development of novel herbicides, fungicides, and plant growth regulators.
• Linker for Bioconjugation: Useful in the design of antibody-drug conjugates (ADCs) and other targeted therapeutic agents.

Basic Information

Product Name	trans-n-Boc-1,4-Cyclohexanediamine-Hcl
CAS No.	946002-43-3
Molecular Formula	C11H23ClN2O2
Molecular Weight	250.77 g/mol
Synonyms	trans-4-[(tert-Butoxycarbonyl)amino]cyclohexylamine hydrochloride; (1r,4r)-4-[(tert-Butoxycarbonyl)amino]cyclohexanamine hydrochloride; trans-1,4-Cyclohexanediamine, N-Boc protected, hydrochloride; trans-4-Amino-N-Boc-cyclohexylamine hydrochloride; trans-4-(Boc-amino)cyclohexylamine HCl; Boc-trans-1,4-diaminocyclohexane hydrochloride; (trans)-4-(Boc-amino)cyclohexanamine hydrochloride
EINECS	Contact for details

Quality Control

Our trans-n-Boc-1,4-Cyclohexanediamine-Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets the high standards required for pharmaceutical R&D and cGMP applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a controlled environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (trans isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.