Description

(1S)-5-Chloro-2,3-Dihydro-1H-Inden-1-Amine CAS NO 945950-78-7 is a high-purity chiral amine building block of significant importance in advanced organic synthesis. Its value lies in its role as a key intermediate for constructing complex molecules with specific stereochemistry, which is critical for developing active pharmaceutical ingredients (APIs) and other fine chemicals. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require enantiomerically pure intermediates for their synthetic pathways.

Application

• As a chiral intermediate in the synthesis of novel pharmaceutical candidates, particularly for central nervous system (CNS) and cardiovascular targets.
• Building block for the development of asymmetric catalysts and ligands used in enantioselective synthesis.
• Key starting material in agrochemical research for creating new herbicides or pesticides with improved efficacy and selectivity.
• Precursor for the synthesis of complex natural product analogs and other bioactive molecules in academic and industrial research settings.
• Intermediate in the production of specialty polymers and advanced materials where specific molecular geometry is required.
• Used in process chemistry for the scale-up and optimization of routes to chiral active pharmaceutical ingredients (APIs).

Basic Information

Product Name	(1S)-5-Chloro-2,3-Dihydro-1H-Inden-1-Amine
CAS No.	945950-78-7
Molecular Formula	C9H10ClN
Molecular Weight	167.63 g/mol
Synonyms	(1S)-5-Chloro-2,3-dihydro-1H-inden-1-amine; (1S)-5-Chloroindan-1-amine; (S)-5-Chloro-2,3-dihydro-1H-inden-1-amine; (S)-5-Chloroindan-1-amine; 5-Chloro-(1S)-indan-1-amine; (1S)-1-Amino-5-chloroindane; (S)-1-Amino-5-chloroindane; 945950-78-7
EINECS	Contact for details

Quality Control

Our production of (1S)-5-Chloro-2,3-Dihydro-1H-Inden-1-Amine adheres to stringent quality protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is characterized using advanced analytical techniques including chiral HPLC, NMR, and GC/MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral excess, and impurity profiles is provided with every shipment, supporting compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.