Description

n-Fmoc-1,6-Diaminohexane Hcl is a high-purity, protected diamine building block essential for solid-phase peptide synthesis (SPPS) and other advanced organic synthesis applications. Its core value lies in providing a stable, orthogonal protecting group strategy for the primary amine, enabling precise and sequential molecular assembly. This compound is critically needed by researchers and manufacturers in pharmaceutical development, biotechnology, and fine chemical synthesis for creating peptide-based therapeutics, diagnostic agents, and complex molecular scaffolds.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled elongation of peptide chains, particularly useful for incorporating lysine-like spacers or linkers.
• Linker and Spacer Chemistry: Used to introduce a flexible hexamethylene spacer arm between functional molecules in bioconjugation, antibody-drug conjugate (ADC) development, and surface functionalization.
• Protecting Group Strategy: The Fmoc (9-fluorenylmethoxycarbonyl) group allows for selective deprotection under mild basic conditions, compatible with a wide range of other protecting groups.
• Combinatorial Chemistry: Serves as a versatile bifunctional building block in the generation of diverse chemical libraries for drug discovery and screening.
• Material Science: Employed in the synthesis of specialized polymers, dendrimers, and functionalized surfaces requiring amine-reactive sites.
• Proteomics Research: Used in the preparation of affinity tags, cross-linking agents, and probes for studying protein interactions and modifications.

Basic Information

Product Name	n-Fmoc-1,6-Diaminohexane Hcl
CAS No.	945923-91-1
Molecular Formula	C₂₁H₂₇ClN₂O₂
Molecular Weight	374.90 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1,6-hexanediamine hydrochloride; 1,6-Hexanediamine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, hydrochloride; Fmoc-1,6-diaminohexane hydrochloride; Fmoc-DAH HCl; Nα-Fmoc-1,6-diaminohexane hydrochloride; N-Fmoc-hexane-1,6-diamine hydrochloride; 1,6-Diaminohexane, N-Fmoc-, hydrochloride; Fmoc-Lys(C6)-OH derivative
EINECS	Contact for details

Quality Control

Our n-Fmoc-1,6-Diaminohexane Hcl is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and cGMP manufacturing. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant pharmacopeial standards and customer-specific requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Purity (HPLC)	≥98.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.