Description

n-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-(Phenylsulfonyl)-4-Quinazolinamine is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is critical for research and development in targeted drug discovery, particularly for kinase inhibition. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel quinazoline-based kinase inhibitors for oncology research.
• Biochemical Research: Used as a reference standard or active probe in enzymatic assays and structure-activity relationship (SAR) studies.
• Preclinical Development: Serves as a crucial material for process chemistry development, formulation studies, and toxicology assessments of candidate drugs.
• Academic Research: Employed in university and institutional labs for medicinal chemistry projects focusing on fluorinated and sulfonylated heterocycles.
• Custom Synthesis: A starting point for contract research organizations (CROs) and CDMOs performing bespoke synthesis for client drug discovery programs.

Basic Information

Product Name	n-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-(Phenylsulfonyl)-4-Quinazolinamine
CAS No.	945553-94-6
Molecular Formula	C20H12ClFN4O4S
Molecular Weight	458.85 g/mol
Synonyms	4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-6-nitro-7-(phenylsulfonyl)-; 945553-94-6; N-(3-Chloro-4-fluorophenyl)-6-nitro-7-(phenylsulfonyl)quinazolin-4-amine; 7-(Benzenesulfonyl)-N-(3-chloro-4-fluorophenyl)-6-nitro-4-quinazolinamine; EGFR Inhibitor Intermediate; Kinase Inhibitor Intermediate; 6-Nitro-7-(phenylsulfonyl)-N-(3-chloro-4-fluorophenyl)-4-quinazolinamine
EINECS	Contact for details

Quality Control

Our n-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-(Phenylsulfonyl)-4-Quinazolinamine is manufactured under strict GMP-like conditions to ensure batch-to-batch consistency and high purity suitable for research applications. Every lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to ICH guidelines for stability and impurity characterization to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture uptake. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	< 20 ppm
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.