Description

(3R,4S)-Rel-1-Boc-3,4-Diaminopyrrolidine is a high-purity, stereochemically defined chiral building block and pharmaceutical intermediate. This compound is of significant value for the synthesis of complex molecules, particularly in medicinal chemistry and asymmetric catalysis, due to its rigid pyrrolidine scaffold and protected diamine functionality. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for developing new active ingredients and ligands.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of protease inhibitors, kinase inhibitors, and other small-molecule therapeutics.
• Asymmetric Catalyst Ligand: Serves as a precursor for chiral ligands used in metal-catalyzed asymmetric synthesis, enabling high enantioselectivity.
• Peptidomimetic Research: Used to construct conformationally constrained peptide analogs and macrocycles for drug discovery.
• Agrochemical Synthesis: Employed in the research and production of advanced, stereospecific agrochemicals.
• Chemical Biology Probes: Utilized to create molecular probes for studying enzyme mechanisms and biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring high stereochemical fidelity.

Basic Information

Product Name	(3R,4S)-Rel-1-Boc-3,4-Diaminopyrrolidine
CAS No.	945217-60-7
Molecular Formula	C9H19N3O2
Molecular Weight	201.27 g/mol
Synonyms	1-Boc-3,4-diaminopyrrolidine, (3R,4S)-rel-; tert-Butyl (3R,4S)-rel-3,4-diaminopyrrolidine-1-carboxylate; (3R,4S)-rel-1-(tert-Butoxycarbonyl)-3,4-diaminopyrrolidine; 1-N-Boc-3,4-diaminopyrrolidine; Pyrrolidine-1-carboxylic acid, 3,4-diamino-, 1,1-dimethylethyl ester, (3R,4S)-rel-; BOC-DAP; rel-(3R,4S)-1-Boc-3,4-diaminopyrrolidine
EINECS	Contact for details

Quality Control

Our (3R,4S)-Rel-1-Boc-3,4-Diaminopyrrolidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with exacting standards for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label. This material is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% de
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.