Description

2-(Trifluoromethyl)-1H-Imidazole-5-Carbaldehyde is a high-value fluorinated heterocyclic building block, essential for synthesizing complex molecules with enhanced biological activity and physicochemical properties. Its core value lies in the strategic introduction of the trifluoromethyl group and aldehyde functionality, which are critical for modulating lipophilicity, metabolic stability, and binding affinity in advanced pharmaceutical intermediates. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and material science industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in protease inhibitors, kinase inhibitors, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group improves efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of organic electronic materials, such as components for OLEDs or conductive polymers.
• Chemical Biology Probes: Utilized to create labeled compounds and molecular probes for studying biological pathways and target engagement.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects.

Basic Information

Product Name	2-(Trifluoromethyl)-1H-Imidazole-5-Carbaldehyde
CAS No.	944905-30-0
Molecular Formula	C5H3F3N2O
Molecular Weight	164.09 g/mol
Synonyms	5-Formyl-2-(trifluoromethyl)-1H-imidazole; 2-(Trifluoromethyl)-1H-imidazole-5-carboxaldehyde; 1H-Imidazole-5-carboxaldehyde, 2-(trifluoromethyl)-; 5-Carbaldehyde-2-trifluoromethylimidazole; 2-Trifluoromethyl-1H-imidazole-5-carbaldehyde; 2-Trifluoromethylimidazole-5-carbaldehyde; 5-Aldehyde-2-trifluoromethylimidazole
EINECS	Contact for details

Quality Control

Our 2-(Trifluoromethyl)-1H-Imidazole-5-Carbaldehyde is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis stages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.