Description

2-Chloropyrimidine-4-Carbaldehyde is a versatile and high-value heterocyclic building block, essential for advanced organic synthesis. Its core value lies in the strategic reactivity of both the chloropyrimidine scaffold and the aldehyde functional group, enabling precise molecular construction. This compound is critically needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors, antiviral agents, and other small-molecule drug candidates targeting various therapeutic areas.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the pyrimidine core's bioactivity.
• Ligand and Catalyst Development: Serves as a starting material for creating complex chelating ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the construction of organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs) due to its rigid, planar structure.
• Chemical Biology Probes: Utilized to develop activity-based probes and molecular tags for studying biological processes and target engagement.
• Cross-Coupling Reactions: The chlorine atom is amenable to palladium-catalyzed cross-coupling (e.g., Suzuki, Buchwald-Hartwig) for rapid diversification.
• Nucleoside Analogue Synthesis: Acts as a building block for modified nucleosides with potential therapeutic applications.

Basic Information

Product Name	2-Chloropyrimidine-4-Carbaldehyde
CAS No.	944901-22-8
Molecular Formula	C5H3ClN2O
Molecular Weight	142.54 g/mol
Synonyms	4-Formyl-2-chloropyrimidine; 2-Chloro-4-pyrimidinecarboxaldehyde; 2-Chloro-4-formylpyrimidine; 2-Chloropyrimidine-4-carboxaldehyde; 4-Pyrimidinecarboxaldehyde, 2-chloro-; (2-Chloropyrimidin-4-yl)methanal
EINECS	Contact for details

Quality Control

Our 2-Chloropyrimidine-4-Carbaldehyde is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent lot-to-lot performance. Certificates of Analysis (COA) with detailed specifications are provided and available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is easily oxidized; for long-term storage, consider keeping under an inert atmosphere such as nitrogen or argon. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.