Description

3-(Trifluoromethyl)-7,8-Dihydroquinolin-5(6H)-One is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters because its unique structure, featuring a trifluoromethyl group fused to a partially saturated quinolinone core, imparts desirable physicochemical properties crucial for developing novel active molecules. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for creating new drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting central nervous system (CNS) and metabolic diseases.
• Agrochemical Research: Serves as a privileged scaffold for designing and synthesizing novel herbicides, fungicides, and insecticides with enhanced efficacy and environmental profile.
• Material Science Precursor: Used in the development of advanced organic electronic materials, such as charge-transport layers or fluorinated polymers, due to its electron-deficient aromatic system.
• Ligand and Catalyst Development: Acts as a starting material for synthesizing novel nitrogen-containing ligands for transition metal catalysis.
• Chemical Biology Probe Synthesis: Employed in the creation of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	3-(Trifluoromethyl)-7,8-Dihydroquinolin-5(6H)-One
CAS No.	944901-18-2
Molecular Formula	C10H8F3NO
Molecular Weight	215.17 g/mol
Synonyms	5,6,7,8-Tetrahydro-3-(trifluoromethyl)quinolin-5-one; 3-Trifluoromethyl-5,6,7,8-tetrahydroquinolin-5-one; 5-Oxo-5,6,7,8-tetrahydro-3-(trifluoromethyl)quinoline; 7,8-Dihydro-3-(trifluoromethyl)quinolin-5(6H)-one; 3-(Trifluoromethyl)-5,6,7,8-tetrahydroquinolin-5-one; 944901-18-2; 3-Trifluoromethyl-7,8-dihydroquinolin-5(6H)-one
EINECS	Contact for details

Quality Control

Our 3-(Trifluoromethyl)-7,8-Dihydroquinolin-5(6H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our commitment to supply chain integrity and batch-to-batch reproducibility meets the stringent requirements of research and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.