Description

tert-Butyl 2-Hydroxy-3,4-Dihydroquinoline-1(2H)-Carboxylate is a high-purity, protected heterocyclic building block of significant interest in advanced organic synthesis. This compound matters because it provides a versatile and reactive scaffold for constructing complex nitrogen-containing molecules, enabling the development of novel pharmaceuticals and agrochemicals. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for applications in medicinal chemistry and catalyst ligand synthesis.

Application

• Pharmaceutical Intermediate: Serves as a key protected precursor in the synthesis of quinoline-based drug candidates, including potential kinase inhibitors and central nervous system (CNS) active agents.
• Agrochemical Research: Used in the development of novel pesticides and herbicides, where the quinoline moiety can impart specific biological activity.
• Organic Synthesis Building Block: The tert-butyloxycarbonyl (Boc) protecting group and the hydroxyl functionality allow for selective derivatization, making it valuable for constructing complex molecular architectures.
• Catalyst & Ligand Development: Acts as a starting material for synthesizing chiral ligands used in asymmetric catalysis, crucial for producing enantiomerically pure compounds.
• Material Science Research: Investigated as a monomer or precursor for functional polymers and advanced organic materials with specific electronic or photophysical properties.

Basic Information

Product Name	tert-Butyl 2-Hydroxy-3,4-Dihydroquinoline-1(2H)-Carboxylate
CAS No.	944467-32-7
Molecular Formula	C₁₄H₁₉NO₃
Molecular Weight	249.31 g/mol
Synonyms	1,2,3,4-Tetrahydro-2-hydroxyquinoline-1-carboxylic acid tert-butyl ester; 2-Hydroxy-1,2,3,4-tetrahydroquinoline-1-carboxylic acid tert-butyl ester; tert-Butyl 2-hydroxy-1,2,3,4-tetrahydroquinoline-1-carboxylate; 1-Boc-2-hydroxy-1,2,3,4-tetrahydroquinoline; 2-Hydroxy-3,4-dihydro-2H-quinoline-1-carboxylic acid tert-butyl ester; Boc-2-hydroxy-tetrahydroquinoline; N-Boc-2-hydroxy-1,2,3,4-tetrahydroquinoline
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-Hydroxy-3,4-Dihydroquinoline-1(2H)-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting full specifications are available for every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under inert atmosphere for prolonged procedures to minimize risk of oxidation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.