Description

Chloro[(S)-(-)-5,5'-Bis(Diphenylphosphino)-4,4'-Bi-1,3-Benzodioxole](p-Cymene)Ruthenium(II) Chloride, commonly referred to as RuCl(p-cymene)[(S)-Segphos], is a highly specialized chiral ruthenium complex designed for asymmetric catalysis. This compound matters because it serves as a precise and efficient catalyst for creating single-enantiomer molecules, which are critical for the bioactivity and safety of advanced materials. It is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries who require high enantioselectivity in hydrogenation and other transition metal-catalyzed reactions.

Application

• Asymmetric Hydrogenation Catalyst: Key for the enantioselective synthesis of chiral alcohols, amines, and other pharmaceutical intermediates.
• Pharmaceutical Intermediate Synthesis: Used in the production of active pharmaceutical ingredients (APIs) requiring high optical purity.
• Agrochemical Manufacturing: Applied in the creation of chiral herbicides, fungicides, and pesticides with enhanced efficacy.
• Fine Chemical Production: Enables the synthesis of specialty flavors, fragrances, and advanced materials.
• Academic and Industrial R&D: A valuable tool for method development and exploring new catalytic transformations in organic chemistry.
• Process Chemistry Optimization: Employed for scaling up enantioselective reactions from laboratory to pilot plant and production scale.

Basic Information

Product Name	Chloro[(S)-(-)-5,5'-Bis(Diphenylphosphino)-4,4'-Bi-1,3-Benzodioxole](p-Cymene)Ruthenium(II) Chloride
CAS No.	944451-29-0
Molecular Formula	C52H44Cl2O4P2Ru
Molecular Weight	964.82 g/mol
Synonyms	RuCl(p-cymene)[(S)-Segphos]; [RuCl((S)-Segphos)(p-cymene)]Cl; (S)-Segphos Ru(p-cymene) chloride complex; Dichloro[(S)-(-)-5,5'-bis(diphenylphosphino)-4,4'-bi-1,3-benzodioxole](p-cymene)ruthenium(II); Ruthenium, dichloro[(1,2,3,4,5,6-η)-1-methyl-4-(1-methylethyl)benzene][(4S)-4,12-bis(diphenylphosphanyl)-2,8,10,16-tetraoxatetracyclo[11.3.1.13,11.15,9]octadeca-1(17),3,5,7,9,11,13,15-octaene]-; (S)-SegPhos Ru(II) p-cymene chloride; Ru-((S)-Segphos)(p-cymene)Cl2
EINECS	Contact for details

Quality Control

Every batch of our chiral ruthenium catalyst is produced and tested under strict quality protocols to ensure consistent high performance and enantioselectivity. Our rigorous quality testing includes advanced analytical techniques to verify chemical identity, purity, and chiral integrity, ensuring compliance with the stringent requirements of pharmaceutical and fine chemical applications. Certificates of Analysis (COA) detailing specific batch results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a dry, cool place. This material is easily oxidized and light-sensitive; prolonged exposure to air or light may degrade catalytic activity.

Specification

Item	Specification
Appearance	Orange to red-brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Ruthenium Content	10.5 - 11.0 %
Solubility	Soluble in dichloromethane, toluene; slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.