Description

Chloro[(R)-(+)-2,2'-Bis(Diphenylphosphino)-5,5',6,6',7,7',8,8'-Octahydro-1,1'-Binaphthyl](p-Cymene)Ruthenium (II) Chloride, commonly referred to as [RuCl(p-cymene)((R)-H8-BINAP)]Cl, is a high-value, chiral ruthenium complex prized for its role as a highly efficient and enantioselective catalyst in asymmetric synthesis. Its importance lies in enabling the production of single-enantiomer intermediates, which are critical for the efficacy and safety of advanced pharmaceuticals and agrochemicals. This product is essential for R&D chemists and process development scientists in the pharmaceutical, fine chemical, and academic research sectors seeking reliable, high-purity catalytic materials.

Application

• Asymmetric Hydrogenation: A premier catalyst for the enantioselective reduction of prochiral olefins, ketones, and imines to produce chiral alcohols and amines.
• Pharmaceutical Intermediate Synthesis: Critical in the synthesis of chiral active pharmaceutical ingredients (APIs) for drugs targeting central nervous system disorders, cardiovascular diseases, and anti-infectives.
• Fine Chemical Manufacturing: Used in the production of high-value chiral flavors, fragrances, and agrochemical intermediates where optical purity is paramount.
• Methodology Development in Academic Research: A key reagent for developing new catalytic asymmetric transformations and studying reaction mechanisms.
• Process Chemistry Optimization: Employed for scaling up enantioselective reactions from laboratory to pilot plant and commercial production.

Basic Information

Product Name	Chloro[(R)-(+)-2,2'-Bis(Diphenylphosphino)-5,5',6,6',7,7',8,8'-Octahydro-1,1'-Binaphthyl](p-Cymene)Ruthenium (II) Chloride
CAS No.	944451-26-7
Molecular Formula	C58H56Cl2P2Ru
Molecular Weight	971.94 g/mol
Synonyms	[RuCl(p-cymene)((R)-H8-BINAP)]Cl; Ruthenium(II) chloro(p-cymene)((R)-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthalene-2,2'-diyl)bis(diphenylphosphine) chloride; (R)-H8-BINAP Ru(p-cymene)Cl complex; (R)-H8-BINAP-Ru(II)(p-cymene) chloride; Dichloro[(R)-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthalene-2,2'-diylbis[diphenylphosphine]](p-cymene)ruthenium(II); RuCl(p-cymene)[(R)-H8-binap]Cl; Asymmetric hydrogenation catalyst Ru-(R)-H8-BINAP.
EINECS	Contact for details

Quality Control

Every batch of our chiral ruthenium catalyst is manufactured and tested under strict quality control protocols to ensure exceptional purity and catalytic performance. We provide comprehensive Certificates of Analysis (COA) detailing key parameters such as assay, enantiomeric purity of the ligand, and residual solvent content. Our quality systems support compliance with cGMP standards for advanced pharmaceutical applications, ensuring traceability and reliability for your critical synthesis projects.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to maintain stability and prevent decomposition. This material is hygroscopic (moisture-sensitive) and easily oxidized; ensure containers are sealed immediately after use.

Specification

Item	Specification
Appearance	Orange to red-brown crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Chiral Purity (HPLC)	≥ 99.0% ee ((R)-H8-BINAP ligand)
Residual Solvents (GC)	Meets ICH guidelines
Elemental Analysis (Ru)	Theoretical ± 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.