Description

3-Amino-3-(1,3-Benzodioxol-5-Yl)-2,2-Dimethylpropionic Acid Hydrochloride is a high-purity, non-proteinogenic amino acid derivative of significant interest in advanced organic synthesis. This compound matters as a sophisticated chiral building block, enabling the development of novel molecules with potential biological activity. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for creating new active ingredients and complex intermediates. Our supply ensures consistent quality and reliable availability for critical development projects.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) targets.
• Agrochemical Synthesis: Used in the development of novel, high-efficacy pesticides and herbicides, leveraging its unique benzodioxole moiety.
• Peptidomimetics Research: Acts as a constrained amino acid analog for designing and synthesizing peptide mimics with enhanced metabolic stability and bioavailability.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands for asymmetric catalysis and metal complexation.
• Academic & Institutional Research: A valuable tool for chemists in universities and research institutes studying synthetic methodology and structure-activity relationships (SAR).
• Bioconjugation Chemistry: Potential use in creating linkers or payloads for antibody-drug conjugates (ADCs) and other bioconjugates due to its functional handles.

Basic Information

Product Name	3-Amino-3-(1,3-Benzodioxol-5-Yl)-2,2-Dimethylpropionic Acid Hydrochloride
CAS No.	944450-98-0
Molecular Formula	C₁₂H₁₅NO₄·HCl
Molecular Weight	273.71 g/mol (Free base: 237.25 g/mol)
Synonyms	3-Amino-3-(1,3-benzodioxol-5-yl)-2,2-dimethylpropanoic acid hydrochloride; 3-Amino-3-(benzo[d][1,3]dioxol-5-yl)-2,2-dimethylpropionic acid HCl; 2,2-Dimethyl-3-amino-3-(3,4-methylenedioxyphenyl)propionic acid hydrochloride; (R/S)-3-Amino-3-(1,3-benzodioxol-5-yl)-2,2-dimethylpropionic acid hydrochloride; 3-(1,3-Benzodioxol-5-yl)-3-amino-2,2-dimethylpropionic acid hydrochloride; 3-Amino-3-(3,4-methylenedioxyphenyl)-2,2-dimethylpropanoic acid hydrochloride
EINECS	Contact for details

Quality Control

Every batch of 3-Amino-3-(1,3-Benzodioxol-5-Yl)-2,2-Dimethylpropionic Acid Hydrochloride is produced and tested under a strict quality management system. We ensure compliance with relevant industry standards for research-grade and development-scale chemicals. Comprehensive analytical testing, including HPLC for purity and chiral purity assessment, is performed. A detailed Certificate of Analysis (COA) providing batch-specific data is available for each shipment upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.