Description

4-Bromo-2-Iodobenzonitrile is a versatile halogenated aromatic nitrile building block of significant importance in modern synthetic chemistry. Its unique structure, featuring both bromine and iodine substituents, makes it a highly valuable intermediate for selective cross-coupling reactions and the construction of complex molecular architectures. This compound is primarily sought after by researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for developing active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting central nervous system disorders and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its reactivity for creating diverse heterocyclic systems.
• Material Science Research: Serves as a building block for organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to its electron-withdrawing nitrile group.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for transition metal catalysis, enabling more efficient and selective synthetic transformations.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Sonogashira, and Buchwald-Hartwig amination reactions, where the differential reactivity of the bromo and iodo groups allows for sequential functionalization.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological processes and protein interactions.

Basic Information

Product Name	4-Bromo-2-Iodobenzonitrile
CAS No.	944276-67-9
Molecular Formula	C7H3BrIN
Molecular Weight	307.92 g/mol
Synonyms	2-Iodo-4-bromobenzonitrile; 4-Bromo-2-iodobenzene carbonitrile; Benzonitrile, 4-bromo-2-iodo-; 2-Iodo-4-bromobenzene-1-carbonitrile; 4-Bromo-2-iodo-benzonitrile; 4-Bromo-2-iodobenzonitrile (CAS 944276-67-9)
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-Iodobenzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment, supporting your R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere when not in use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.