Description

2-(Difluoromethoxy)Isonicotinonitrile is a specialized pyridine derivative featuring a difluoromethoxy substituent and a nitrile functional group, making it a valuable fluorinated building block for advanced synthesis. This compound is critical for researchers and manufacturers developing novel active pharmaceutical ingredients (APIs) and agrochemicals, where the introduction of fluorine atoms can dramatically alter biological activity and metabolic stability. It is primarily sought after by the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the difluoromethoxy group enhances lipophilicity and target binding.
• Fluorinated Building Block: Serves as a versatile precursor in organic synthesis for introducing fluorinated motifs into more complex chemical structures.
• Material Science Research: Employed in the development of specialty chemicals, liquid crystals, and functional materials requiring specific electronic properties.
• Chemical Reference Standard: Used as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	2-(Difluoromethoxy)Isonicotinonitrile
CAS No.	943845-24-7
Molecular Formula	C7H4F2N2O
Molecular Weight	170.12 g/mol
Synonyms	4-Cyano-2-(difluoromethoxy)pyridine; 2-(Difluoromethoxy)isonicotinonitrile; 4-Pyridinecarbonitrile, 2-(difluoromethoxy)-; Isonicotinonitrile, 2-(difluoromethoxy)-; 2-Difluoromethoxy-isonicotinonitrile; 2-Difluoromethoxy-4-cyanopyridine; 943845-24-7 (CAS)
EINECS	Contact for details

Quality Control

Our 2-(Difluoromethoxy)Isonicotinonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity intermediates for GMP and research use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.