Description

8-[2-Nitro-4-(Trifluoromethyl)Phenyl]-1,4-Dioxa-8-Azaspiro-[4,5]-Decane is a high-value, advanced pharmaceutical intermediate characterized by its unique spirocyclic and nitro-trifluoromethylphenyl structure. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs) and agrochemicals, offering a versatile building block for introducing specific functional groups into target molecules. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for creating novel compounds with enhanced biological activity.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, leveraging the trifluoromethyl group for improved efficacy and environmental profile.
• Fine Chemical Production: Serves as a precursor for specialized dyes, pigments, and functional materials requiring specific nitro-aromatic and heterocyclic motifs.
• Academic & Industrial R&D: Employed in medicinal chemistry and chemical biology research for structure-activity relationship (SAR) studies and library synthesis.
• Material Science: Potential intermediate for the development of organic electronic materials and photoactive compounds.

Basic Information

Product Name	8-[2-Nitro-4-(Trifluoromethyl)Phenyl]-1,4-Dioxa-8-Azaspiro-[4,5]-Decane
CAS No.	942474-81-9
Molecular Formula	C16H17F3N2O4
Molecular Weight	358.32 g/mol
Synonyms	8-[2-Nitro-4-(trifluoromethyl)phenyl]-1,4-dioxa-8-azaspiro[4.5]decane; 1,4-Dioxa-8-azaspiro[4.5]decane, 8-[2-nitro-4-(trifluoromethyl)phenyl]-; 8-(2-Nitro-4-trifluoromethylphenyl)-1,4-dioxa-8-azaspiro[4.5]decane; 942474-81-9; Spiro[1,4-dioxa-8-azacyclopentane-5,1'-cyclopentane], 8-[2-nitro-4-(trifluoromethyl)phenyl]- (CAS Index Name).
EINECS	Contact for details

Quality Control

Our production of 8-[2-Nitro-4-(Trifluoromethyl)Phenyl]-1,4-Dioxa-8-Azaspiro-[4,5]-Decane adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. All materials undergo comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles to meet your specific R&D or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.