Description

8-[5-(Trifluoromethyl)Pyridin-2-Yl]-1,4-Dioxa-8-Azaspiro[4.5]Decane is a high-value, fluorinated spirocyclic building block essential for modern organic synthesis. Its core value lies in its unique molecular architecture, which combines a trifluoromethylpyridine moiety with a protected 1,4-dioxa-8-azaspiro[4.5]decane scaffold, making it a critical intermediate for developing novel active compounds. This compound is primarily needed by R&D and process chemistry teams in the pharmaceutical and agrochemical industries for the discovery and scale-up of new chemical entities.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing novel drug candidates, particularly in central nervous system (CNS) and metabolic disease research.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity and stability.
• Chemical Biology Probe Development: Serves as a scaffold for creating tool compounds to study biological pathways and protein function.
• Material Science Research: Investigated as a precursor for specialty polymers and advanced materials with specific fluorinated properties.
• Medicinal Chemistry Library Synthesis: Employed in the parallel and combinatorial synthesis of diverse compound libraries for high-throughput screening.
• Process Chemistry & Scale-Up: Supplied for route scouting, optimization, and pilot-scale production of target molecules.

Basic Information

Product Name	8-[5-(Trifluoromethyl)Pyridin-2-Yl]-1,4-Dioxa-8-Azaspiro[4.5]Decane
CAS No.	942474-71-7
Molecular Formula	C14H15F3N2O2
Molecular Weight	300.28 g/mol
Synonyms	8-[5-(Trifluoromethyl)-2-pyridinyl]-1,4-dioxa-8-azaspiro[4.5]decane; 1,4-Dioxa-8-azaspiro[4.5]decane, 8-[5-(trifluoromethyl)-2-pyridinyl]-; 8-(5-(Trifluoromethyl)pyridin-2-yl)-1,4-dioxa-8-azaspiro[4.5]decane; 942474-71-7; 8-(5-Trifluoromethyl-2-pyridyl)-1,4-dioxa-8-azaspiro[4.5]decane; Spirocyclic Pyridine Derivative; Trifluoromethylpyridine Spiroketal Amine.
EINECS	Contact for details

Quality Control

Our 8-[5-(Trifluoromethyl)Pyridin-2-Yl]-1,4-Dioxa-8-Azaspiro[4.5]Decane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and structural identity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring traceability and compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.