Description

1H-Pyrrolo[2,3-B]Pyridine, 4-Chloro-2-Iodo- is a high-purity halogenated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters as a versatile and critical intermediate for constructing complex molecular architectures, particularly in pharmaceutical research and development. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of kinase inhibitors and other targeted therapeutic agents.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides with specific modes of action.
• Material Science: Serves as a precursor for organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors.
• Cross-Coupling Reactions: The iodine and chlorine substituents make it an excellent substrate for Suzuki, Sonogashira, and Buchwald-Hartwig amination reactions.
• Medicinal Chemistry SAR Studies: Enables structure-activity relationship exploration by allowing selective functionalization at the halogen sites.
• Chemical Biology Probes: Used to create labeled compounds for studying biological pathways and target engagement.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine, 4-Chloro-2-Iodo-
CAS No.	940948-29-8
Molecular Formula	C7H4ClIN2
Molecular Weight	278.48 g/mol
Synonyms	4-Chloro-2-iodo-1H-pyrrolo[2,3-b]pyridine; 4-Chloro-2-iodo-7-azaindole; 2-Iodo-4-chloro-1H-pyrrolo[2,3-b]pyridine; 4-Chloro-2-iodo-1H-7-azaindole; 1H-Pyrrolo[2,3-b]pyridine, 4-chloro-2-iodo-; 940948-29-8; 4-Chloro-2-iodo-7-aza-indole
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine, 4-Chloro-2-Iodo- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency suitable for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.