Description

5-Ethynylpicolinaldehyde is a high-purity, versatile alkyne-functionalized heterocyclic building block essential for advanced organic synthesis. This compound is particularly valued for its dual reactive sites—the aldehyde and terminal alkyne groups—enabling efficient cross-coupling and cycloaddition reactions. It is a critical intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries developing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of kinase inhibitors, antiviral agents, and other small molecule therapeutics via click chemistry and Sonogashira coupling.
• Agrochemical Research: Used in creating novel pesticide and herbicide candidates with enhanced activity and selectivity.
• Ligand Synthesis: Serves as a precursor for constructing sophisticated chelating ligands used in catalysis and metal-organic frameworks (MOFs).
• Material Science: Employed in the development of conjugated polymers and advanced organic electronic materials due to its π-conjugated system.
• Bioconjugation: Facilitates the site-specific labeling of biomolecules (proteins, nucleic acids) for diagnostics and bioimaging applications.
• Academic & R&D: A valuable reagent for methodological development in synthetic organic chemistry and heterocyclic chemistry.

Basic Information

Product Name	5-Ethynylpicolinaldehyde
CAS No.	940911-03-5
Molecular Formula	C8H5NO
Molecular Weight	131.13 g/mol
Synonyms	5-Ethynylpyridine-2-carboxaldehyde; 2-Pyridinecarboxaldehyde, 5-ethynyl-; 5-Ethynyl-2-formylpyridine; 5-Ethynyl-2-pyridinecarboxaldehyde; 5-Ethynylpicolinaldehyde; 5-Ethynylpicolinaldehyde; Aldehyde, 5-ethynylpicolin-; 940911-03-5
EINECS	Contact for details

Quality Control

Our 5-Ethynylpicolinaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and production. Comprehensive Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.