Description

5,7-Difluoro-1,2,3,4-Tetrahydroquinoline is a fluorinated heterocyclic building block of significant importance in modern synthetic chemistry. Its value lies in its role as a key intermediate for constructing more complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is primarily needed by R&D chemists and process development scientists working on the synthesis of novel active ingredients, where the introduction of fluorine atoms is a critical strategy for modulating biological activity, metabolic stability, and lipophilicity.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) drugs, kinase inhibitors, and anti-infective agents.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the difluoro-tetrahydroquinoline scaffold contributes to efficacy and environmental profile.
• Material Science Research: Serves as a monomer or functional component in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Fluorine Chemistry & Catalysis: Acts as a model substrate in methodological studies for novel fluorination reactions and catalytic C-H functionalization processes.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.

Basic Information

Product Name	5,7-Difluoro-1,2,3,4-Tetrahydroquinoline
CAS No.	939758-78-8
Molecular Formula	C9H9F2N
Molecular Weight	169.17 g/mol
Synonyms	5,7-Difluoro-1,2,3,4-tetrahydroquinoline; 1,2,3,4-Tetrahydro-5,7-difluoroquinoline; 5,7-Difluoro-3,4-dihydro-2H-quinoline; 5,7-Difluoro-1,2,3,4-tetrahydro-quinoline; 5,7-Difluorotetrahydroquinoline; DFTHQ; 939758-78-8
EINECS	Contact for details

Quality Control

Our 5,7-Difluoro-1,2,3,4-Tetrahydroquinoline is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality system is designed to meet the stringent requirements of cGMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents and strong acids. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Typical 98-99%)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.