Description

5-Trifluoromethyl-1,2,3,4-Tetrahydro-Quinoline Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a unique trifluoromethylated tetrahydroquinoline scaffold. This compound is valued for its role in modulating the physicochemical and metabolic properties of target molecules, making it a critical building block in modern drug discovery. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, especially those targeting neurological disorders and cancer.
• Agrochemical Research: Used in the synthesis of advanced molecules for crop protection and pesticide development, leveraging the stability imparted by the trifluoromethyl group.
• Material Science Precursor: Serves as a specialized building block for creating functionalized organic materials and ligands for catalysis.
• Academic & Contract Research: Essential for medicinal chemistry programs in academic laboratories and contract research organizations (CROs) for structure-activity relationship (SAR) studies.

Basic Information

Product Name	5-Trifluoromethyl-1,2,3,4-Tetrahydro-Quinoline Hydrochloride
CAS No.	939758-74-4
Molecular Formula	C10H11ClF3N
Molecular Weight	237.65 g/mol
Synonyms	5-(Trifluoromethyl)-1,2,3,4-tetrahydroquinoline hydrochloride; 5-Trifluoromethyl-1,2,3,4-tetrahydroquinoline HCl; 1,2,3,4-Tetrahydro-5-(trifluoromethyl)quinoline hydrochloride; Quinoline, 1,2,3,4-tetrahydro-5-(trifluoromethyl)-, hydrochloride; 939758-74-4
EINECS	Contact for details

Quality Control

Every batch of 5-Trifluoromethyl-1,2,3,4-Tetrahydro-Quinoline Hydrochloride is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent batch-to-batch quality suitable for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.