Description

2,3-Dihydro-Benzo[1,4]Oxazine-2,4-Dicarboxylic Acid 4-tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in research and development for central nervous system (CNS) and other therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic research institutions engaged in medicinal chemistry and process development.

Application

• Key Intermediate in Pharmaceutical Synthesis: Serves as a crucial building block for the development of new drug candidates, especially those targeting neurological pathways.
• Medicinal Chemistry Research: Used in the design and synthesis of novel benzoxazine derivatives for biological activity screening and structure-activity relationship (SAR) studies.
• Process Chemistry & Scale-Up: Employed in the optimization and pilot-scale production of complex molecules for pre-clinical and clinical trials.
• Fine Chemical Manufacturing: A specialized intermediate for the production of high-value, custom-synthesized compounds for the life sciences industry.
• Academic & Institutional Research: Utilized in university and research institute laboratories for exploratory synthetic chemistry and new methodology development.

Basic Information

Product Name	2,3-Dihydro-Benzo[1,4]Oxazine-2,4-Dicarboxylic Acid 4-tert-Butyl Ester
CAS No.	939525-77-6
Molecular Formula	C15H17NO5
Molecular Weight	291.30 g/mol
Synonyms	4-(tert-Butyl) 2-methyl 2,3-dihydro-1,4-benzoxazine-2,4-dicarboxylate; 4-tert-Butyl 2,3-dihydro-1,4-benzoxazine-2,4-dicarboxylate; 1,4-Benzoxazine-2,4-dicarboxylic acid, 2,3-dihydro-, 4-(1,1-dimethylethyl) ester; Benzo[1,4]oxazine-2,4-dicarboxylic acid, 2,3-dihydro-, 4-tert-butyl ester; 939525-77-6; tert-Butyl 2,3-dihydrobenzo[1,4]oxazine-4-carboxylate-2-carboxylate (tautomeric form).
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support development and commercial projects requiring material suitable for use under cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.