Description

(S)-5-Amino-1-((2-(Trimethylsilyl)Ethoxy)Methyl)-1,3-Dihydrospiro[Indene-2,3-Pyrrolo[2,3-B]Pyridin]-2(1H)-One (Wx145563) is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and fused heterocyclic structure. This compound is of significant value for medicinal chemistry research and development, particularly in the synthesis of targeted small molecule therapeutics. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of novel drug candidates, especially in oncology and other disease areas requiring sophisticated molecular scaffolds.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of novel active pharmaceutical ingredients (APIs) with potential kinase inhibitory or other targeted biological activities.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) due to its complex, three-dimensional spirocyclic core.
• Process Chemistry Development: Serves as a critical intermediate in scaling up synthetic routes for preclinical and clinical trial material manufacturing.
• Bioconjugation & Probe Synthesis: The amino functional group allows for further derivatization to create chemical probes for biological target identification and validation studies.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services for the global biopharma industry.

Basic Information

Item	Details
Product Name	(S)-5-Amino-1-((2-(Trimethylsilyl)Ethoxy)Methyl)-1,3-Dihydrospiro[Indene-2,3-Pyrrolo[2,3-B]Pyridin]-2(1H)-One (Wx145563)
CAS No.	939016-96-3
Molecular Formula	C24H30N4O2Si
Molecular Weight	434.62 g/mol
Synonyms	WX-145563; (S)-WX145563; (S)-5-Amino-1-((2-(trimethylsilyl)ethoxy)methyl)-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one; 1,3-Dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one, 5-amino-1-[[2-(trimethylsilyl)ethoxy]methyl]-, (S)-; SEM-Protected Spirocyclic Amino Pyrrolopyridine; (S)-5-Amino-1-SEM-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one
EINECS	Contact for details

Quality Control

Our (S)-5-Amino-1-((2-(Trimethylsilyl)Ethoxy)Methyl)-1,3-Dihydrospiro[Indene-2,3-Pyrrolo[2,3-B]Pyridin]-2(1H)-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) when opening the primary container to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.