Description

2-Amino-5-Bromoquinazolin-4-Ol is a specialized brominated quinazoline derivative, a key heterocyclic building block in advanced organic synthesis. This compound matters for its role as a versatile precursor in the development of novel pharmacologically active molecules, particularly kinase inhibitors and other targeted therapeutics. Pharmaceutical R&D laboratories and fine chemical manufacturers need it for constructing complex molecular architectures where a functionalized quinazoline core is required.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of potential kinase inhibitors (e.g., EGFR, VEGFR inhibitors) and other biologically active quinazoline-based compounds.
• Agrochemical Research: Used in the development of new active ingredients for crop protection, leveraging the bioactivity of the quinazoline scaffold.
• Material Science: Serves as a precursor for creating functional organic materials, such as ligands for metal-organic frameworks (MOFs) or organic semiconductors.
• Chemical Biology: Employed in the design and synthesis of molecular probes and tool compounds for studying enzyme function and cellular pathways.
• Academic & Contract Research: Essential for medicinal chemistry programs in universities and CROs (Contract Research Organizations) focused on heterocyclic chemistry and drug discovery.

Basic Information

Product Name	2-Amino-5-Bromoquinazolin-4-Ol
CAS No.	937668-63-8
Molecular Formula	C8H6BrN3O
Molecular Weight	240.06 g/mol
Synonyms	5-Bromo-2-amino-4-hydroxyquinazoline; 4-Hydroxy-5-bromo-2-aminoquinazoline; 2-Amino-5-bromo-4(3H)-quinazolinone; 5-Bromo-2-amino-4(3H)-quinazolinone; 937668-63-8; 2-Amino-5-bromoquinazolin-4(3H)-one; 5-Bromo-2-aminoquinazolin-4-ol
EINECS	Contact for details

Quality Control

Our 2-Amino-5-Bromoquinazolin-4-Ol is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.