Description

4-Chloro-7-Ethoxy-6-Nitroquinazoline is a high-purity, advanced pharmaceutical intermediate characterized by its specific halogenated quinazoline structure. This compound matters as a critical building block in the synthesis of targeted therapeutic agents, particularly kinase inhibitors used in oncology research. It is primarily needed by pharmaceutical R&D departments, contract research organizations (CROs), and fine chemical manufacturers engaged in developing novel drug candidates.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of tyrosine kinase inhibitor (TKI) drug candidates for cancer therapy.
• Oncology Research: Serves as a core scaffold for the development and structure-activity relationship (SAR) studies of novel anti-cancer compounds.
• Chemical Synthesis: Used in nucleophilic substitution reactions where the chloro group is displaced to introduce new functional moieties.
• Process Development: Employed in scaling up and optimizing synthetic routes for active pharmaceutical ingredients (APIs) under GMP conditions.
• Academic & Institutional Research: Utilized in medicinal chemistry programs for designing and testing new quinazoline-based molecules.

Basic Information

Product Name	4-Chloro-7-Ethoxy-6-Nitroquinazoline
CAS No.	936954-10-8
Molecular Formula	C₁₀H₈ClN₃O₃
Molecular Weight	253.64 g/mol
Synonyms	4-Chloro-7-ethoxy-6-nitroquinazoline; 6-Nitro-7-ethoxy-4-chloroquinazoline; 7-Ethoxy-4-chloro-6-nitroquinazoline; Quinazoline, 4-chloro-7-ethoxy-6-nitro-; 936954-10-8; 4-Chloro-7-ethoxy-6-nitro-quinazoline; 4-Chloro-6-nitro-7-ethoxyquinazoline
EINECS	Contact for details

Quality Control

Our 4-Chloro-7-Ethoxy-6-Nitroquinazoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are available upon request, providing full traceability and compliance documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.