Description

4,6-Dichloro-8-Fluoro-Quinoline-3-Carbonitrile is a high-purity, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in its versatile reactivity, serving as a key precursor for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs). This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries who require reliable, high-quality intermediates for their synthetic pipelines.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel quinoline-based drug candidates, including potential kinase inhibitors, antimicrobials, and anticancer agents.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and pesticides, leveraging the biological activity of the fluorinated quinoline scaffold.
• Material Science Precursor: Serves as a starting material for creating specialized organic ligands, dyes, and photoactive compounds for advanced materials.
• Chemical Synthesis Reagent: Employed in cross-coupling reactions, cyclizations, and functional group transformations to introduce the dichloro-fluoro-quinoline moiety into target molecules.
• Academic & R&D: A valuable tool for medicinal chemistry and organic synthesis research in university and corporate laboratories.

Basic Information

Product Name	4,6-Dichloro-8-Fluoro-Quinoline-3-Carbonitrile
CAS No.	936498-06-5
Molecular Formula	C10H3Cl2FN2
Molecular Weight	241.05 g/mol
Synonyms	8-Fluoro-4,6-dichloroquinoline-3-carbonitrile; 4,6-Dichloro-8-fluoroquinoline-3-carbonitrile; 3-Cyano-4,6-dichloro-8-fluoroquinoline; Quinoline-3-carbonitrile, 4,6-dichloro-8-fluoro-; 936498-06-5; 4,6-Dichloro-8-fluoro-3-quinolinecarbonitrile
EINECS	Contact for details

Quality Control

Our 4,6-Dichloro-8-Fluoro-Quinoline-3-Carbonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.