Description

4-Chloro-6,8-Difluoro-Quinoline-3-Carbonitrile is a high-purity, multi-functional heterocyclic building block of significant importance in advanced organic synthesis. Its unique halogenated quinoline structure makes it a critical intermediate for the development of novel active pharmaceutical ingredients (APIs) and specialty agrochemicals. This compound is primarily sought by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and material science sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in antimicrobial, anticancer, and central nervous system (CNS) therapeutic areas.
• Agrochemical Research: Serves as a core building block for developing next-generation herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science: Used in the research and development of advanced organic electronic materials, such as OLEDs and semiconductors, due to its electron-deficient quinoline core.
• Chemical Synthesis: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic substitution reactions to introduce complex functionalities.
• Ligand & Catalyst Development: Acts as a precursor for creating novel nitrogen-containing ligands used in homogeneous catalysis.
• Fluorescent Probe Synthesis: Its structure is suitable for modifying to create dyes and fluorescent markers for biological imaging and sensing applications.

Basic Information

Product Name	4-Chloro-6,8-Difluoro-Quinoline-3-Carbonitrile
CAS No.	936498-00-9
Molecular Formula	C10H3ClF2N2
Molecular Weight	224.59 g/mol
Synonyms	4-Chloro-6,8-difluoroquinoline-3-carbonitrile; 6,8-Difluoro-4-chloroquinoline-3-carbonitrile; 3-Cyano-4-chloro-6,8-difluoroquinoline; Quinoline-3-carbonitrile, 4-chloro-6,8-difluoro-; 936498-00-9; 4-Chloro-6,8-difluoro-3-quinolinecarbonitrile
EINECS	Contact for details

Quality Control

Our 4-Chloro-6,8-Difluoro-Quinoline-3-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our commitment to cGMP and ISO standards ensures a reliable supply of high-purity material for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to prevent moisture absorption and contamination. Store away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.