Description

1-Bromo-2-(difluoromethoxy)-3,5-difluorobenzene is a high-value, multi-fluorinated aromatic building block essential for advanced synthesis. This compound is prized for its unique substitution pattern, which introduces both halogen and difluoromethoxy functionalities critical for modulating the electronic and steric properties of target molecules. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for constructing complex active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the development of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, where the difluoromethoxy group enhances biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for advanced display technologies.
• Organic Electronics: Employed in the construction of electron-deficient aromatic cores for organic semiconductors and light-emitting materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to create complex biaryl structures.
• Fluorine Chemistry Research: A valuable reagent for studying structure-activity relationships (SAR) and the effects of fluorine substitution in medicinal and materials chemistry.

Basic Information

Product Name	1-Bromo-2-(Difluoromethoxy)-3,5-Difluorobenzene
CAS No.	936249-93-3
Molecular Formula	C7H3BrF4O
Molecular Weight	258.99 g/mol
Synonyms	2-Bromo-1,3-difluoro-4-(difluoromethoxy)benzene; 3,5-Difluoro-2-(difluoromethoxy)bromobenzene; Benzene, 1-bromo-2-(difluoromethoxy)-3,5-difluoro-; 1-Bromo-3,5-difluoro-2-(difluoromethoxy)benzene; 2-(Difluoromethoxy)-1,3-difluoro-4-bromobenzene
EINECS	Contact for details

Quality Control

Our 1-Bromo-2-(difluoromethoxy)-3,5-difluorobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flames. This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.